Computational Insights into the Inhibitory Mechanism of Human AKT1 by an Orally Active Inhibitor, MK-2206
Author:
Publisher
Public Library of Science (PLoS)
Subject
Multidisciplinary
Reference42 articles.
1. Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway;AM Martelli;Leukemia,2011
2. Targeting the phosphoinositide 3-kinase pathway in cancer;P Liu;Nat Rev Drug Discov,2009
3. The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module;N Kannan;Proc Natl Acad Sci USA,2007
4. Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation;J Yang;Mol Cell,2002
5. Advances in protein kinase B signalling: AKTion on multiple fronts;DP Brazil;Trends Biochem Sci,2004
Cited by 46 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Design, synthesis and cytotoxic evaluation of new thieno[2,3-d]pyrimidine analogues as VEGFR-2/AKT dual inhibitors, apoptosis and autophagy inducers;Bioorganic Chemistry;2024-09
2. Substrate preference of protein kinase B isoforms can vary depending on the cell line;PLOS ONE;2024-03-19
3. Integrating machine learning and high throughput screening for the discovery of allosteric AKT1 inhibitors;Journal of Biomolecular Structure and Dynamics;2023-12-14
4. Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest;Molecular Cell;2023-11
5. Differential activation of AKT isoforms by growth factors in human myotubes;Physiological Reports;2023-10
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3