Integrating machine learning and high throughput screening for the discovery of allosteric AKT1 inhibitors
Author:
Affiliation:
1. School of Biosciences and Technology, Vellore Institute of Technology, Vellore, India
Publisher
Informa UK Limited
Subject
Molecular Biology,General Medicine,Structural Biology
Link
https://www.tandfonline.com/doi/pdf/10.1080/07391102.2023.2293265
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1. Tetrahydro-pyrimido-indoles as selective LIMK inhibitors: synthesis, selectivity profiling and structure–activity studies
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3. AGC protein kinases: From structural mechanism of regulation to allosteric drug development for the treatment of human diseases
4. Discovery and Optimization of a Series of 3-(3-Phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: Orally Bioavailable, Selective, and Potent ATP-Independent Akt Inhibitors
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