Author:
Gao Huiping,Wang Haiying,Shan Guangliang,Liu Rui,Chen Haiyuan,Sun Shengli,Liu Yonglin
Abstract
Objective
Dyslipidemia is a leading risk factor for cardiovascular and cerebrovascular diseases. By collecting the blood lipid profiles among adult residents of Shenmu City in Shaanxi Province, China, we aim to assess and elucidate the prevalence and risk factors of dyslipidemia in this city.
Method
Stratified multistage sampling was used to survey 4,598 permanent adult residents in five areas of Shenmu (2 communities in the county seat, 2 in the southern area and 2 in the northern area) from September 2019 to December 2019. Questionnaire surveys and physical examinations were conducted. Data were analyzed using SPSS software version 26.0.
Results
The average level of total cholesterol (TC) is 4.47mmol/L, that of triglyceride (TG) 1.32mmol/L, high-density lipoprotein cholesterol (HDL-C) 1.27mmol/L, apolipoprotein A1 (ApoA1) 1.44g/L, low-density lipoprotein cholesterol (LDL-C) 2.7mmol/L and apolipoprotein B (ApoB) 0.97g/L. The prevalence of hypercholesterolemia (HTC), hypertriglyceridemia (HTG), low high-density lipoprotein (HDL-C) and high low-density lipoprotein (LDL-C) is 22.4%, 33.3%, 14.5%, and 5.81%, respectively, and the overall prevalence of dyslipidemia is 48.27%. Furthermore, blood lipid levels and prevalence of dyslipidemia vary by region, age, gender, occupation and educational level. Nine risk factors of dyslipidemia were identified, which are living in county seat or northern industrial area, increasing age, male, overweight or obesity, abdominal obesity, smoking, hypertension, abnormal glucose metabolism (pre-diabetes or diabetes) and hyperuricemia.
Conclusion
The blood lipid levels and dyslipidemia prevalence of adults in Shenmu City are higher comparing to national averages of China. Combining risk factors of dyslipidemia, early detection and public health interventions are necessary in high-risk population for associated cardiovascular and cerebrovascular diseases prevention.
Funder
Natural Science Foundation of Shaanxi Province
Shenmu Municipal Government Scientific Research Project (2019) No.5
Publisher
Public Library of Science (PLoS)
Reference29 articles.
1. Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015;GA Roth;J Am Coll Cardiol,2017
2. HDL cholesterol protects against cardiovascular disease in both genders, at all ages and at all levels of risk;MT Cooney;Atherosclerosis,2009
3. 2016 Chinese guideline for the management of dyslipidemia in adults;J Zhu;Chinese Journal of Circulation,2016
4. Increased plasma lipid levels exacerbate muscle pathology in the mdx mouse model of Duchenne muscular dystrophy;N Milad;Skelet Muscle,2017
5. Prevalence of dyslipidemia and associated risk factors among adult residents of Mekelle City, Northern Ethiopia;G Gebreegziabiher;PLoS One,2021