Specificity Rendering ‘Hot-Spots’ for Aurora Kinase Inhibitor Design: The Role of Non-Covalent Interactions and Conformational Transitions
Author:
Publisher
Public Library of Science (PLoS)
Subject
Multidisciplinary
Reference88 articles.
1. Aurora-A kinase inhibitor scaffolds and binding modes;A Yan;Drug Discov Today,2011
2. Mitotic kinases as regulators of cell division and its checkpoints;EA Nigg;Nat Rev Mol Cell Biol,2001
3. Aurora kinases as targets for cancer therapy;G Mountzios;Cancer Treat Rev,2008
4. Aurora A and B kinases-targets of novel anticancer drugs;S Libertini;Recent Pat Anticancer Drug Discov,2010
5. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo;EA Harrington;Nat,2004
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