Reversible Linkage of Two Distinct Small Molecule Inhibitors of Myc Generates a Dimeric Inhibitor with Improved Potency That Is Active in Myc Over-Expressing Cancer Cell Lines

Author:

Wanner Jutta,Romashko Darlene,Werner Douglas S.,May Earl W.,Peng Yue,Schulz Ryan,Foreman Kenneth W.,Russo Suzanne,Arnold Lee D.,Pingle Maneesh,Bergstrom Donald E.,Barany Francis,Thomson Stuart

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference37 articles.

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3. Assembling ligands in situ using bioorthogonal boronate ester synthesis;SB Shin;Chem Biol,2010

4. Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors;M Demetriades;Angew Chem Int Ed Engl,2012

5. The relationship among pKa, pH and binding constants in the interactions between boronic acids and diols- it is not as simple as it appears;J Yan;Tetrahedron,2004

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