The use of 18F-Fluoro-deoxy-glucose positron emission tomography (18F-FDG PET) as a non-invasive pharmacodynamic biomarker to determine the minimally pharmacologically active dose of AZD8835, a novel PI3Kα inhibitor-Reference-Cited by-同舟云学术

The use of 18F-Fluoro-deoxy-glucose positron emission tomography (18F-FDG PET) as a non-invasive pharmacodynamic biomarker to determine the minimally pharmacologically active dose of AZD8835, a novel PI3Kα inhibitor

Published:2017-08-14 Issue:8 Volume:12 Page:e0183048
ISSN:1932-6203
Container-title:PLOS ONE
language:en
Short-container-title:PLoS ONE

Author:

Maynard Juliana,Emmas Sally-Ann,Ble Francois-Xavier,Barjat Herve,Lawrie Emily,Hancox Urs,Polanska Urszula M.,Pritchard Alison,Hudson Kevin

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference25 articles.

1. Targeting the PI3K/AKT/mTOR pathway beyond rapalogs;B Markman;Oncotarget,2010

2. PI3K pathway alterations in cancer: variations on a theme;TL Yuan;Oncogene,2008

3. PIK3CA mutations, phosphatase and tensin homolog, human epidermal growth factors receptor 2, and insulin-like growth factor 1 receptor and adjuvant tamoxifen resistance in postmenopausal breast cancer patients;K Beelen;Breast Cancer Research,2014

4. Development of PI3K inhibitors lessons learned from early clinical trials;J Rodon;Nat Rev Clin Oncol,2013

5. BYL719, a new α-specific PI3K inhibitor: single administration and in combination with conventional chemotherapy for the treatment of osteosarcoma;B Gobin;Int J Cancer,2015

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