Characterization of Phosphofructokinase Activity in Mycobacterium tuberculosis Reveals That a Functional Glycolytic Carbon Flow Is Necessary to Limit the Accumulation of Toxic Metabolic Intermediates under Hypoxia

Author:

Phong Wai Yee,Lin Wenwei,Rao Srinivasa P. S.,Dick Thomas,Alonso Sylvie,Pethe Kevin

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference43 articles.

1. World Health Organization (2011) Global Tuberculosis Control.

2. Tuberculosis - metabolism and respiration in the absence of growth;HIM Boshoff;Nat Rev Microbiol,2005

3. Media for tubercle bacilli;R Dubos;Am Rev Tuberc,1947

4. Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase;J McKinney;Nature,2000

5. Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence;EJ Muñoz-Elías;Nat Med,2005

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