Psychosine enhances the shedding of membrane microvesicles: Implications in demyelination in Krabbe’s disease

Author:

D’Auria Ludovic,Reiter Cory,Ward Emma,Moyano Ana Lis,Marshall Michael S.,Nguyen Duc,Scesa Giuseppe,Hauck Zane,van Breemen Richard,Givogri Maria I.,Bongarzone Ernesto R.ORCID

Funder

National Institute of Neurological Disorders and Stroke

Legacy of Angels Foundation

European Leukodystrophy Association

National Multiple Sclerosis Society

Partners for Krabbe Research

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference70 articles.

1. Progressive accumulation of toxic metabolite in a genetic leukodystrophy;H Igisu;Science,1984

2. Insights into the Pathogenesis and Treatment of Krabbe Disease;ER Bongarzone;Pediatr Endocrinol Rev,2016

3. Psychosine accumulates in membrane microdomains in the brain of krabbe patients, disrupting the raft architecture;AB White;The Journal of neuroscience: the official journal of the Society for Neuroscience,2009

4. Trans interactions between galactosylceramide and cerebroside sulfate across apposed bilayers;JM Boggs;Biophys J,2000

5. How the molecular features of glycosphingolipids affect domain formation in fluid membranes;B Westerlund;Biochim Biophys Acta,2009

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