On the influence of prior information evaluated by fully Bayesian criteria in a personalized whole-brain model of epilepsy spread
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Published:2021-07-14
Issue:7
Volume:17
Page:e1009129
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ISSN:1553-7358
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Container-title:PLOS Computational Biology
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language:en
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Short-container-title:PLoS Comput Biol
Author:
Hashemi MeysamORCID,
Vattikonda Anirudh N.ORCID,
Sip ViktorORCID,
Diaz-Pier SandraORCID,
Peyser AlexanderORCID,
Wang HuifangORCID,
Guye MaximeORCID,
Bartolomei Fabrice,
Woodman Marmaduke M.,
Jirsa Viktor K.ORCID
Abstract
Individualized anatomical information has been used as prior knowledge in Bayesian inference paradigms of whole-brain network models. However, the actual sensitivity to such personalized information in priors is still unknown. In this study, we introduce the use of fully Bayesian information criteria and leave-one-out cross-validation technique on the subject-specific information to assess different epileptogenicity hypotheses regarding the location of pathological brain areas based on a priori knowledge from dynamical system properties. The Bayesian Virtual Epileptic Patient (BVEP) model, which relies on the fusion of structural data of individuals, a generative model of epileptiform discharges, and a self-tuning Monte Carlo sampling algorithm, is used to infer the spatial map of epileptogenicity across different brain areas. Our results indicate that measuring the out-of-sample prediction accuracy of the BVEP model with informative priors enables reliable and efficient evaluation of potential hypotheses regarding the degree of epileptogenicity across different brain regions. In contrast, while using uninformative priors, the information criteria are unable to provide strong evidence about the epileptogenicity of brain areas. We also show that the fully Bayesian criteria correctly assess different hypotheses about both structural and functional components of whole-brain models that differ across individuals. The fully Bayesian information-theory based approach used in this study suggests a patient-specific strategy for epileptogenicity hypothesis testing in generative brain network models of epilepsy to improve surgical outcomes.
Funder
Agence Nationale de la Recherche
Human Brain Project SGA2 and SGA3
European Union’s Horizon 2020 Framework Programme for Research and Innovation
VirtualBrainCloud
PHRC-I 2013 EPISODIUM
Fondation Générale de Santé
SATT Sud-Est
Publisher
Public Library of Science (PLoS)
Subject
Computational Theory and Mathematics,Cellular and Molecular Neuroscience,Genetics,Molecular Biology,Ecology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics
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