The Polyurethane-Drug Composites: Synthesis, Properties and a Kinetic Model

Abstract

Oligoglycol-based polyurethane composites were synthesized and filled with an antibiotic—cephasoline. Using mechanical testing as well as IR-spectroscopy and HPLC methods, the properties of these composites were studied as biodegradable carriers for medicinal substances. Cephasoline was found to be released at an appreciable rate from the polyurethane carriers into a physiological solution at 37°C. A catalyst (Fe tris-acetylacetonate) added to the cephasoline-polyurethane system not only helped to optimize the polymerization process but also provided for steady release of cephasoline in vitro during a long time.