Affiliation:
1. Instituto de Química Médica, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain
Abstract
Glycogen synthase kinase 3 (GSK-3), a proline/serine protein kinase ubiquitously expressed and involved in many cellular signaling pathways, plays a key role in the pathogenesis of Alzheimer's disease (AD) being probably the link betweenβ-amyloid and tau pathology. A great effort has recently been done in the discovery and development of different new molecules, of synthetic and natural origin, able to inhibit this enzyme, and several kinetics mechanisms of binding have been described. The small molecule called tideglusib belonging to the thiadiazolidindione family is currently on phase IIb clinical trials for AD. The potential risks and benefits of this new kind of disease modifying drugs for the future therapy of AD are discussed in this paper.
Subject
Behavioral Neuroscience,Cellular and Molecular Neuroscience,Cognitive Neuroscience,Clinical Neurology,Neurology,Ageing
Cited by
71 articles.
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