Genome sequence analysis of Ebola virus in clinical samples from three British healthcare workers, August 2014 to March 2015-Reference-Cited by-同舟云学术

Genome sequence analysis of Ebola virus in clinical samples from three British healthcare workers, August 2014 to March 2015

Published:2015-05-21 Issue:20 Volume:20 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Bell A¹²,Lewandowski K²¹,Myers R³,Wooldridge D³,Aarons E¹,Simpson A¹,Vipond R¹⁴,Jacobs M⁵,Gharbia S⁴³,Zambon M³

Affiliation:

1. Public Health England, Porton Down, Salisbury, United Kingdom

2. These authors contributed equally to the work and are joint first authors

3. Public Health England, Colindale, London, United Kingdom

4. NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, United Kingdom

5. Department of Infection, Royal Free London NHS Foundation Trust, London, United Kingdom

Abstract

We determined complete viral genome sequences from three British healthcare workers infected with Ebola virus (EBOV) in Sierra Leone, directly from clinical samples. These sequences closely resemble those previously observed in the current Ebola virus disease outbreak in West Africa, with glycoprotein and polymerase genes showing the most sequence variation. Our data indicate that current PCR diagnostic assays remain suitable for detection of EBOV in this epidemic and provide confidence for their continued use in diagnosis.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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