Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019-Reference-Cited by-同舟云学术

Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019

Published:2019-09-19 Issue:38 Volume:24 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Roberts David J¹,Davis Grahame S¹,Cole Michelle J¹,Naik Dixita¹,Maru Hitiksha¹,Woodford Neil¹,Muir Peter²,Horner Paddy³,Simms Ian¹,Thickett George¹,Crook Paul⁴,Foster Kirsty⁵,Andrews Nick⁶,Saunders John¹,Fifer Helen¹,Folkard Kate¹,Gill O Noel¹,

Affiliation:

1. National Infection Service, Public Health England, London, United Kingdom

2. South West Regional Public Health Laboratory, Public Health England, Bristol, United Kingdom

3. Population Health Sciences, University of Bristol, Bristol, United Kingdom

4. Field Service South East and London, Public Health England, London, United Kingdom

5. Public Health England North East Centre, Newcastle-upon-Tyne, United Kingdom

6. Statistics, Modelling and Economics Department, Public Health England, London, United Kingdom

Abstract

We identified two new Chlamydia trachomatis (CT) variants escaping Aptima Combo 2 (AC2) assay detection, in clinical specimens of two patients. One had a C1514T mutation the other a G1523A mutation, both within the AC2 23S rRNA target region. The prevalence of such variants among persons tested for CT in England was estimated to be fewer than 0.003%.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference16 articles.

1. Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019.;Rantakokko-Jalava;Euro Surveill,2019

2. Letter to the editor: Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019.;Unemo;Euro Surveill,2019

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