Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019

Author:

Rantakokko-Jalava Kaisu12,Hokynar Kati3,Hieta Niina14,Keskitalo Anniina12,Jokela Pia5,Muotiala Anna6,Jokiranta T. Sakari7,Kuusela Rutta8,Sarkkinen Hannu9,Aittoniemi Janne10,Vuorinen Tytti12,Hakanen Antti J12,Puolakkainen Mirja5

Affiliation:

1. University of Turku, Turku, Turku, Finland

2. Department of Clinical Microbiology, Turku University Hospital, Turku, Finland

3. Department of virology, University of Helsinki, Helsinki, Finland

4. Venereal Diseases Outpatient Clinic, Turku University Hospital, Turku, Finland

5. Department of Virology and Immunology, University of Helsinki and Helsinki University Hospital, Huslab, Helsinki, Finland

6. United Medix Laboratories Ltd, Helsinki, Finland

7. Synlab Finland Ltd, Helsinki, Finland

8. Satadiag, Pori, Finland

9. Fimlab, Lahti, Finland

10. Fimlab Laboratories, Tampere, Finland

Abstract

Since February 2019, over 160 Chlamydia trachomatis (CT) cases testing negative or equivocal by Aptima Combo 2 (AC2) but positive by Aptima CT test run with Panther instruments occurred in Finland. The AC2 test targets chlamydial 23S rRNA while the CT test targets 16S rRNA. Sequencing of 10 strains revealed a nucleotide substitution in 23S rRNA. The significance of this for the failure of the AC2 test to detect the variant is not yet known.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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