Hepatitis A outbreak in HIV-infected MSM and in PrEP-using MSM despite a high level of immunity, Lyon, France, January to June 2017

Author:

Charre Caroline12,Ramière Christophe312,Roque-Afonso Anne-Marie4,Chidiac Christian51,Zoulim Fabien671,Godinot Matthieu8,Koffi Joseph75,Scholtès Caroline612,Livrozet Jean-Michel8,Cotte Laurent5,

Affiliation:

1. Université de Lyon, Lyon, France

2. Laboratoire de Virologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France

3. CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France

4. National reference centre for hepatitis A virus (Centre national de référence du virus de l’hépatite A), Virologie, Hôpital Paul Brousse, AP-HP, Villejuif, France

5. Service de maladie infectieuse et tropicale, Hôpital de la Croix Rousse, Hospices Civils de Lyon, Lyon, France

6. INSERM, U871, Lyon, France

7. Service d’Hépatologie et de gastroentérologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France

8. Service de maladie infectieuse et tropicale, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France

Abstract

Since 2016, an increase in the number of hepatitis A cases affecting mainly men who have sex with men (MSM) has been reported in low endemic countries in Europe. We calculated the attack rate in Lyon, France, in populations considered at high-risk: HIV-infected MSM and HIV-negative MSM receiving HIV pre-exposure prophylaxis (PrEP). In these populations, high level of immunity did not prevent the outbreak, indicating that vaccination should be reinforced, particularly in younger individuals.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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