The ‘Finnish new variant of Chlamydia trachomatis’ escaping detection in the Aptima Combo 2 assay is widespread across Norway, June to August 2019-Reference-Cited by-同舟云学术

The ‘Finnish new variant of Chlamydia trachomatis’ escaping detection in the Aptima Combo 2 assay is widespread across Norway, June to August 2019

Published:2019-10-17 Issue:42 Volume:24 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Johansen Tone Bjordal¹²,Kløvstad Hilde²,Rykkvin Rikard²,Herrfurth-Erichsen Einar Bredo³,Sorthe Joakim³,Njølstad Gro⁴,Ebbesen Marit Helen⁴,Nygaard Randi Monsen⁴,Sandmoen Ellen Kristin⁵,Thilesen Carina⁶,Onken Annette⁷,Liljedal Inger⁸,Hadad Ronza⁹,Unemo Magnus⁹

Affiliation:

1. European Public Health Microbiology Training Programme (EUPHEM), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden

2. Norwegian Institute of Public Health, Oslo, Norway

3. Fürst Medical Laboratory, Oslo, Norway

4. Haukeland University Hospital, Bergen, Norway

5. Tønsberg Hospital Trust, Department of Medical Microbiology, Tønsberg, Norway

6. Unilabs Laboratory Medicine, Department of Medical Microbiology, Skien, Norway

7. Vestre Viken Hospital Trust, Department of Microbiology, Drammen, Norway

8. Levanger Hospital, Department for Laboratory Medicine, Levanger, Norway

9. WHO Collaborating Centre for Gonorrhoea and other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden

Abstract

The ‘Finnish new variant of Chlamydia trachomatis’ (FI-nvCT), escaping detection in the Aptima Combo 2 assay (AC2), is widespread across Norway. From June to August 2019, 84% (81/97) of available AC2/Aptima CT discordant samples from five laboratories were confirmed as FI-nvCT. Two additional CT variants (CT 23S rRNA C1514T and G1523A) also escaped AC2 detection. The high FI-nvCT proportion might indicate a long-term national spread and it cannot be excluded that FI-nvCT emerged in Norway.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference13 articles.

1. Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019.;Rantakokko-Jalava;Euro Surveill,2019

2. The Finnish New Variant of Chlamydia trachomatis with a Single Nucleotide Polymorphism in the 23S rRNA Target Escapes Detection by the Aptima Combo 2 Test.;Hokynar;Microorganisms,2019

3. Finnish new variant of Chlamydia trachomatis escaping detection in the Aptima Combo 2 assay also present in Örebro County, Sweden, May 2019.;Unemo;Euro Surveill,2019

4. Letter to the editor: Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019.;Unemo;Euro Surveill,2019

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