Product-specific COVID-19 vaccine effectiveness against secondary infection in close contacts, Navarre, Spain, April to August 2021

Author:

Martínez-Baz Iván123ORCID,Trobajo-Sanmartín Camino41ORCID,Miqueleiz Ana41,Guevara Marcela123ORCID,Fernández-Huerta Miguel41,Burgui Cristina123,Casado Itziar123ORCID,Portillo María Eugenia41,Navascués Ana41,Ezpeleta Carmen41,Castilla Jesús123ORCID,

Affiliation:

1. Navarra Institute for Health Research (IdiSNA), Pamplona, Spain

2. CIBER Epidemiología y Salud Pública (CIBERESP), Spain

3. Instituto de Salud Pública de Navarra, Pamplona, Spain

4. Clinical Microbiology Department, Complejo Hospitalario de Navarra, Pamplona, Spain

Abstract

COVID-19 vaccine effectiveness by product (two doses Comirnaty, Spikevax or Vaxzevria and one of Janssen), against infection ranged from 50% (95% CI: 42 to 57) for Janssen to 86% (70 to 93) for Vaxzevria-Comirnaty combination; among ≥ 60 year-olds, from 17% (−26 to 45) for Janssen to 68% (48 to 80) for Spikevax; and against hospitalisation from 74% (43 to 88) for Janssen to > 90% for other products. Two doses of vaccine were highly effective against hospitalisation, but suboptimal for infection control.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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