Vaccine effectiveness against SARS-CoV-2 transmission and infections among household and other close contacts of confirmed cases, the Netherlands, February to May 2021

Author:

de Gier Brechje1ORCID,Andeweg Stijn1,Joosten Rosa1,ter Schegget Ronald2,Smorenburg Naomi1,van de Kassteele Jan1,Hahné Susan JM1,van den Hof Susan1,de Melker Hester E1,Knol Mirjam J1,

Affiliation:

1. Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands

2. GGD Brabant Zuidoost, Eindhoven, the Netherlands

Abstract

Several studies report high effectiveness of COVID-19 vaccines against SARS-CoV-2 infection and severe disease, however an important knowledge gap is the vaccine effectiveness against transmission (VET). We present estimates of the VET to household and other close contacts in the Netherlands, from February to May 2021, using contact monitoring data. The secondary attack rate among household contacts was lower for fully vaccinated than unvaccinated index cases (11% vs 31%), with an adjusted VET of 71% (95% confidence interval: 63–77).

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference8 articles.

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3. Mumps vaccine effectiveness in primary schools and households, the Netherlands, 2008.;Snijders;Vaccine,2012

4. Estimating vaccine efficacy from secondary attack rates.;Halloran;J Am Stat Assoc,2003

5. Harris RJ, Hall JA, Zaidi A, Andrews NJ, Dunbar JK, Dabrera G. Impact of vaccination on household transmission of SARS-COV-2 in England. London: Knowledge Hub; 2021. Available from: https://khub.net/documents/135939561/390853656/Impact+of+vaccination+on+household+transmission+of+SARS-COV-2+in+England.pdf/35bf4bb1-6ade-d3eb-a39e-9c9b25a8122a?t=1619551571214

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