Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023-Reference-Cited by-同舟云学术

Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023

Published:2023-09-14 Issue:37 Volume:28 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Maubaret Clara¹²³⁴,Caméléna François³¹⁴²^ORCID,Mrimèche Manel²³⁴,Braille Aymeric²³,Liberge Mathilde²³⁴,Mainardis Mary²³,Guillaume Clémence⁵,Noel Franck⁶,Bébéar Cécile⁷⁸^ORCID,Molina Jean-Michel⁹¹⁰,Lot Florence¹¹,Chazelle Emilie¹¹,Berçot Béatrice²³⁴^ORCID

Affiliation:

1. These authors contributed equally to this work and share first authorship.

2. French National Reference Centre for bacterial STI, Associated Laboratory for Gonococci, Paris, France

3. APHP, Infectious Agents Department, Saint Louis - Lariboisière University Hospitals, Paris, France

4. Paris Cité University, INSERM1137, IAME, Paris, France

5. Orléans Hospital, Microbiology Laboratory, Orléans, France

6. Bioxa Laboratoire, Microbiology Laboratory, Bezannes, France

7. University Hospital, Bacteriology Department, French National Reference Centre for Bacterial STIs, Bordeaux France

8. University of Bordeaux, USC EA 3671 Mycoplasmal and Chlamydial Infections in Humans, Bordeaux, France

9. AP-HP, Infectious Disease Department, Saint Louis – Lariboisière Hospitals, Paris, France

10. Paris Cité University, INSERM, UMR S976, Paris, France

11. Santé publique France, the national public health agency, Saint-Maurice, France

Abstract

We report two extensively drug-resistant (XDR) Neisseria gonorrhoeae (NG) isolates combining high-level resistance to azithromycin and resistance to ceftriaxone, obtained in France from two heterosexual patients, one of whom returned from Cambodia. Whole genome sequencing identified MLST ST16406, the mosaic penA-60.001 which caused ceftriaxone resistance in the internationally spreading FC428 clone, and the A2059G mutation in the 23S rRNA gene. The NG isolates F93 and F94 were related to XDR isolates detected in Austria and the United Kingdom in 2022.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference21 articles.

1. Meeting the public health challenge of multidrug- and extensively drug-resistant Neisseria gonorrhoeae.;Tapsall;Expert Rev Anti Infect Ther,2009

2. The European response to control and manage multi- and extensively drug-resistant Neisseria gonorrhoeae.;Cole;Euro Surveill,2022

3. Detection of 10 cases of ceftriaxone-resistant Neisseria gonorrhoeae in the United Kingdom, December 2021 to June 2022.;Day;Euro Surveill,2022

4. Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022.;Pleininger;Euro Surveill,2022

5. Pelvic inflammatory diseases: Updated French guidelines.;Brun;J Gynecol Obstet Hum Reprod,2020

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