Vaccine effectiveness against SARS-CoV-2 transmission to household contacts during dominance of Delta variant (B.1.617.2), the Netherlands, August to September 2021

Author:

de Gier Brechje1ORCID,Andeweg Stijn1,Backer Jantien A1,Hahné Susan JM1,van den Hof Susan1,de Melker Hester E1,Knol Mirjam J1,

Affiliation:

1. Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands

Abstract

We estimated SARS-CoV-2 vaccine effectiveness against onward transmission by comparing secondary attack rates among household members for vaccinated and unvaccinated index cases, based on source and contact tracing data collected when the Delta variant was dominant. Effectiveness of full vaccination of the index case against transmission to unvaccinated and fully vaccinated household contacts, respectively, was 63% (95% confidence interval (CI): 46–75) and 40% (95% CI: 20–54), in addition to the direct protection of vaccination of contacts against infection.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference12 articles.

1. Vaccine effectiveness against SARS-CoV-2 transmission and infections among household and other close contacts of confirmed cases, the Netherlands, February to May 2021.;de Gier;Euro Surveill,2021

2. Netherlands to reopen further with coronavirus entry passes. The Hague: Government of the Netherlands; 2021.Available from: https://www.government.nl/latest/news/2021/09/14/netherlands-to-reopen-further-with-coronavirus-entry-passes

3. Coronavirus variants. The Hague: Dutch government; 2021.Available from: https://coronadashboard.government.nl/landelijk/varianten

4. Estimating vaccine efficacy from secondary attack rates.;Halloran;J Am Stat Assoc,2003

5. The R package geepack for generalized estimating equations.;Højsgaard;J Stat Softw,2005

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