Evaluation of commercial and automated SARS-CoV-2 IgG and IgA ELISAs using coronavirus disease (COVID-19) patient samples-Reference-Cited by-同舟云学术

Evaluation of commercial and automated SARS-CoV-2 IgG and IgA ELISAs using coronavirus disease (COVID-19) patient samples

Published:2020-05-07 Issue:18 Volume:25 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Jääskeläinen Anne J¹,Kekäläinen Eliisa¹,Kallio-Kokko Hannimari¹,Mannonen Laura¹,Kortela Elisa²,Vapalahti Olli¹,Kurkela Satu³¹,Lappalainen Maija³¹

Affiliation:

1. Department of Virology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

2. Infectious diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

3. These authors contributed equally to the work

Abstract

Antibody-screening methods to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) need to be validated. We evaluated SARS-CoV-2 IgG and IgA ELISAs in conjunction with the EUROLabworkstation (Euroimmun, Lübeck, Germany). Overall specificities were 91.9% and 73.0% for IgG and IgA ELISAs, respectively. Of 39 coronavirus disease patients, 13 were IgG and IgA positive and 11 IgA alone at sampling. IgGs and IgAs were respectively detected at a median of 12 and 11 days after symptom onset.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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