Novel vancomycin resistance gene cluster in Enterococcus faecium ST1486, Belgium, June 2021-Reference-Cited by-同舟云学术

Novel vancomycin resistance gene cluster in Enterococcus faecium ST1486, Belgium, June 2021

Published:2021-09-09 Issue:36 Volume:26 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Xavier Basil Britto¹²^ORCID,Coppens Jasmine³,De Koster Sien¹²,Rajakani Sahaya Glingston¹²,Van Goethem Sam³,Mzougui Samy⁴,Anantharajah Ahalieyah⁴,Lammens Christine¹²,Loens Katherine⁵³,Glupczynski Youri¹²,Goossens Herman⁵³¹²,Matheeussen Veerle⁵³

Affiliation:

1. Vaccine and Infectious Disease Institute, Universiteit Antwerpen, Wilrijk, Belgium

2. Laboratory of Medical Microbiology, Universiteit Antwerpen, Wilrijk, Belgium

3. Laboratory of Clinical Microbiology, Antwerp University Hospital, Edegem, Belgium

4. Laboratory of Clinical Microbiology, Cliniques Universitaires Saint-Luc-UCLouvain, Brussels, Belgium

5. Belgian National Reference Centre for Enterococci, Antwerp University Hospital, Edegem, Belgium

Abstract

We identified a novel van gene cluster in a clinical Enterococcus faecium isolate with vancomycin minimum inhibitory concentration (MIC) of 4 µg/mL. The ligase gene, vanP, was part of a van operon cluster of 4,589 bp on a putative novel integrative conjugative element located in a ca 98 kb genomic region presumed to be acquired by horizontal gene transfer from Clostridium scidens and Roseburia sp. 499. Screening for van genes in E. faecium strains with borderline susceptibility to vancomycin is important.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference18 articles.

1. Vancomycin-resistant enterococci: why are they here, and where do they come from?;Bonten;Lancet Infect Dis,2001

2. Enterococcus faecium: from microbiological insights to practical recommendations for infection control and diagnostics.;Zhou;Antimicrob Resist Infect Control,2020

3. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis.;Tacconelli;Lancet Infect Dis,2018

4. Xavier, B.B., et al., BacPipe: A rapid, user-friendly whole-genome sequencing pipeline for clinical diagnostic bacteriology. iScience. 2020;23(1):100769.

5. Improved annotation of antibiotic resistance determinants reveals microbial resistomes cluster by ecology.;Gibson;ISME J,2015

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