Tetrahydrobiopterin-dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells-Reference-Cited by-同舟云学术

Tetrahydrobiopterin-dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells

Published:1992-01-15 Issue:2 Volume:281 Page:297-300
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Schmidt K¹,Werner E R²,Mayer B¹,Wachter H²,Kukovetz W R¹

Affiliation:

1. Institut für Pharmakodynamik und Toxikologie, Universität Graz, Universitätsplatz 2, A-8010 Graz, Austria

2. Medizinische Chemie und Biochemie, Universität Innsbruck, Innsbruck, Austria

Abstract

Inhibition of tetrahydrobiopterin (H4biopterin) biosynthesis in endothelial cells almost completely abolished the agonist-induced formation of endothelium-derived relaxing factor (EDRF) (NO). This inhibitory effect could be antagonized when H4biopterin biosynthesis was restored by activating a salvage pathway. These data indicate that the formation of EDRF strictly depends on the presence of intracellular H4biopterin, which, in addition to Ca2+, may represent a further physiological and/or pathophysiological regulatory of endothelial NO synthases.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/281/2/297/605868/bj2810297.pdf

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