Lysosomal phospholipase A1 in Trypanosoma cruzi: an enzyme with a possible role in the pathogenesis of Chagas’ disease-Reference-Cited by-同舟云学术

Lysosomal phospholipase A1 in Trypanosoma cruzi: an enzyme with a possible role in the pathogenesis of Chagas’ disease

Published:2001-04-24 Issue:3 Volume:355 Page:765-770
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

WAINSZELBAUM Marisa¹,ISOLA Estela¹,WILKOWSKY Silvina¹,CANNATA Joaquin J. B.²,FLORIN-CHRISTENSEN Jorge³,FLORIN-CHRISTENSEN Monica³

Affiliation:

1. Department of Microbiology, University of Buenos Aires (UBA) School of Medicine, Paraguay 2155, piso 13, (RA-2111) Buenos Aires, Argentina,

2. Center for Bioenergetics Research (CIBIERG), CONICET-UBA, Paraguay 2155, piso 16, (RA-2111) Buenos Aires, Argentina

3. Institute of Neuroscience (INEUCI), CONICET-UBA, Ciudad University, Pab. II, piso 4, (RA-1428) Buenos Aires, Argentina

Abstract

We found that, as in African trypanosomes, endogenous phospholipase A1 (Plase A1) activity can catalyse extensive deacylation of phospholipids upon cell death in all life stages of Trypanosoma cruzi. A major lysosomal Plase A1 was purified and characterized. The enzyme products can explain the lesions surrounding degenerating T. cruzi cells in host tissues. Thus Plase A1 emerges as a target to block pathogenesis in trypanosomal infections.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/355/3/765/706992/bj3550765.pdf

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