Biosynthesis of putrescine in the prostate gland of the rat

Author:

Pegg A E1,Williams-Ashman H G1

Affiliation:

1. James Buchanan Brady Urological Institute, Johns Hopkins Hospital, and Department of Pharmacology and Experimental Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Md. 21205, U.S.A.

Abstract

In the rat ventral prostate gland the biosynthesis of putrescine, a precursor of spermidine and spermine, is shown to occur by the direct decarboxylation of l-ornithine. Some properties of a soluble pyridoxal phosphate-dependent l-ornithine decarboxylase are described. The findings are discussed in relation to other enzymic reactions involved in the biosynthesis of polyamines by the prostate gland.

Publisher

Portland Press Ltd.

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