Double-stranded-RNA-activated protein kinase (PKR) regulates Ca2+ stores in Xenopus oocytes-Reference-Cited by-同舟云学术

Double-stranded-RNA-activated protein kinase (PKR) regulates Ca2+ stores in Xenopus oocytes

Published:1998-03-01 Issue:2 Volume:330 Page:599-603
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

THOMAS David¹,KIM Hak Yong¹,MORGAN Roseline¹,HANLEY R. Michael¹

Affiliation:

1. Department of Biological Chemistry, School of Medicine, University of California, Davis, CA 95616, U.S.A.

Abstract

Expression of the double-stranded-RNA-dependent protein kinase (PKR) in Xenopus oocytes attenuated Ca2+ entry-dependent membrane currents activated by depletion of Ca2+ stores, whereas expression of a dominant-negative PKR mutant had the opposite effect. These results appeared to be due to perturbation of releasable Ca2+ stores, and not actions of PKR on protein synthesis. PKR may thus have novel protein substrates and cellular functions in Ca2+ storage and signalling.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/330/2/599/632880/bj3300599.pdf

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