Effect of Deficiency of the Double-Stranded RNA-Dependent Protein Kinase, PKR, on Antiviral Resistance in the Presence or Absence of Ribonuclease L: HSV-1 Replication Is Particularly Sensitive to Deficiency of the Major IFN-Mediated Enzymes-Reference-Cited by-同舟云学术

Effect of Deficiency of the Double-Stranded RNA-Dependent Protein Kinase, PKR, on Antiviral Resistance in the Presence or Absence of Ribonuclease L: HSV-1 Replication Is Particularly Sensitive to Deficiency of the Major IFN-Mediated Enzymes

Published:2000-07 Issue:7 Volume:20 Page:653-659
ISSN:1079-9907
Container-title:Journal of Interferon & Cytokine Research
language:en
Short-container-title:Journal of Interferon & Cytokine Research

Author:

Khabar Khalid S. A.¹,Dhalla Mohammed²,Siddiqui Yunus²,Zhou Amin³,Al-Ahdal Mohammed N.²,Der Sandy D.³,Silverman Robert H.³,Williams Bryan R. G.³

Affiliation:

1. Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia and Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, OH 44195.

2. Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.

3. Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, OH 44195.

Publisher

Mary Ann Liebert Inc

Subject

Virology,Cell Biology,Immunology

Link

http://www.liebertpub.com/doi/pdf/10.1089/107999000414835

Reference19 articles.

1. HOW CELLS RESPOND TO INTERFERONS

2. A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon.

3. Inhibition of mRNA binding to ribosomes by localized activation of dsRNA-dependent protein kinase