Evidence for altered expression of the GTP-dependent regulatory proteins, Gs and Gi, in adipocytes from aged rats-Reference-Cited by-同舟云学术

Evidence for altered expression of the GTP-dependent regulatory proteins, Gs and Gi, in adipocytes from aged rats

Published:1989-03-01 Issue:2 Volume:258 Page:607-610
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Green A¹,Johnson J L¹

Affiliation:

1. Departments of Internal Medicine and Pharmacology and Toxicology, University of Texas Medical Branch, Route E68, Galveston, TX 77550, U.S.A.

Abstract

The alpha-subunits of Gi and Gs were quantified in adipocyte membranes from young (2-month) and older (18-month) rats by pertussis-toxin and cholera-toxin labelling respectively. Aging was associated with a 3-fold increase in Gi alpha-subunit, but only a 2-fold increase in one of the two Gs alpha-subunit species labelled. The findings may explain the altered sensitivity of adipocytes from aged rats to lipolytic and anti-lipolytic stimuli.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/258/2/607/595552/bj2580607.pdf

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. In-depth analysis of Gαs protein activity by probing different fluorescently labeled guanine nucleotides;Biological Chemistry;2024-02-02

2. Characteristics of metabolic changes in adipocytes of growing rats;Biochimie;2016-06

3. Effect of maturation and aging on β-adrenergic signal transduction in rat kidney and liver;Biochemical Pharmacology;2000-12

4. Differentiation of cultured brown adipocytes is associated with a selective increase in the short variant of Gsα protein. Evidence for higher functional activity of GsαS;Molecular and Cellular Endocrinology;2000-09

5. Lipid metabolism in the elderly;European Journal of Clinical Nutrition;2000-06