Affiliation:
1. London Respiratory Muscle Group, Royal Brompton & Harefield NHS Trust, Sydney Street, London SW3 6NP, U.K.
2. Respiratory Muscle Laboratory, King's College London School of Medicine, King's College Hospital, Bessemer Road, London SE5 9PJ, U.K.
Abstract
Skeletal muscle dysfunction in COPD (chronic obstructive pulmonary disease) patients, particularly of the quadriceps, is of clinical interest because it not only influences the symptoms that limit exercise, but may also contribute directly to poor exercise performance and health status, increased healthcare utilization, and mortality. Furthermore, unlike the largely irreversible impairment of the COPD lung, skeletal muscles represent a potential site to improve patients' level of function and quality of life. However, despite expanding knowledge of potential contributing factors and greater understanding of molecular mechanisms of muscle wasting, only one intervention has been shown to be effective in reversing COPD muscle dysfunction, namely exercise training. Pulmonary rehabilitation, an intervention based on individually tailored exercise training, has emerged as arguably the most effective non-pharmacological intervention in improving exercise capacity and health status in COPD patients. The present review describes the effects of chronic exercise training on skeletal muscles and, in particular, focuses on the known effects of pulmonary rehabilitation on the quadriceps muscle in COPD. We also describe the current methods to augment the effects of pulmonary rehabilitation and speculate how greater knowledge of the molecular pathways of skeletal muscle wasting may aid the development of novel pharmaceutical agents.
Reference121 articles.
1. Skeletal muscle dysfunction in COPD: clinical and laboratory observations;Man;Clin. Sci.,2009
2. Exercise training fails to increase skeletal muscle enzymes in patients with chronic obstructive pulmonary disease;Belman;Am. Rev. Respir. Dis.,1981
3. Pulmonary rehabilitation for chronic obstructive pulmonary disease;Lacasse;Cochrane Database Syst. Rev.,2002
4. American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation;Nici;Am. J. Respir. Crit. Care Med.,2006
5. Pulmonary rehabilitation in chronic obstructive pulmonary disease;Troosters;Am. J. Respir. Crit. Care Med.,2005
Cited by
46 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献