Mitochondrial oxygen sensing: regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species-Reference-Cited by-同舟云学术

Mitochondrial oxygen sensing: regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species

Published:2007-08-10 Issue: Volume:43 Page:17-28
ISSN:0071-1365
Container-title:Essays in Biochemistry
language:en
Short-container-title:

Author:

Bell Eric L.¹,Chandel Navdeep S.¹²

Affiliation:

1. Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, U.S.A.

2. Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, U.S.A.

Abstract

Decreased oxygen availability (hypoxia) promotes physiological processes such as energy metabolism, angiogenesis, cell proliferation and cell viability through the transcription factor HIF (hypoxia-inducible factor). Activation of HIF can also promote pathophysiological processes such as cancer and pulmonary hypertension. The mechanism(s) by which hypoxia activates HIF are the subject of intensive research. In this chapter we outline the model in which mitochondria regulate the stability of HIF through the increased production of ROS (reactive oxygen species) during hypoxia.

Publisher

Portland Press Ltd.

Subject

Molecular Biology,Biochemistry

Link

https://portlandpress.com/essaysbiochem/article-pdf/doi/10.1042/bse0430017/915106/bse0430017.pdf

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