PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex-Reference-Cited by-同舟云学术

PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex

Published:2004-07-27 Issue:3 Volume:381 Page:587-592
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

CARLISLE MICHEL Jennifer J.¹,DODGE Kimberly L.¹,WONG Wei¹,MAYER Nicole C.¹,LANGEBERG Lorene K.¹,SCOTT John D.¹

Affiliation:

1. Howard Hughes Medical Institute and Vollum Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, U.S.A.

Abstract

mAKAP (muscle-selective A-kinase-anchoring protein) co-ordinates a cAMP-sensitive negative-feedback loop comprising PKA (cAMP-dependent protein kinase) and the cAMP-selective PDE4D3 (phosphodiesterase 4D3). In vitro and cellular experiments demonstrate that PKA-phosphorylation of PDE4D3 on Ser-13 increases the affinity of PDE4D3 for mAKAP. Our data suggest that activation of mAKAP-anchored PKA enhances the recruitment of PDE4D3, allowing for quicker signal termination.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/381/3/587/718913/bj3810587.pdf

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