Poly(A)-binding protein (PABP): a common viral target-Reference-Cited by-同舟云学术

Poly(A)-binding protein (PABP): a common viral target

Published:2010-01-27 Issue:1 Volume:426 Page:1-12
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Smith Richard W. P.¹,Gray Nicola K.²

Affiliation:

1. 1MRC Human Reproductive Sciences Unit, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, U.K., and School of Clinical Sciences and Community Health, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, U.K.

2. 2MRC Human Reproductive Sciences Unit, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, U.K., and School of Clinical Sciences and Community Health, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, U.K.

Abstract

Cytoplasmic PABP [poly(A)-binding protein] is a multifunctional protein with well-studied roles in mRNA translation and stability. In the present review, we examine recent evidence that the activity of PABP is altered during infection with a wide range of viruses, bringing about changes in its stability, complex formation and intracellular localization. Targeting of PABP by both RNA and DNA viruses highlights the role of PABP as a central regulator of gene expression.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/426/1/1/660331/bj4260001.pdf

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