53BP1: function and mechanisms of focal recruitment-Reference-Cited by-同舟云学术

53BP1: function and mechanisms of focal recruitment

Published:2009-07-22 Issue:4 Volume:37 Page:897-904
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

FitzGerald Jennifer E.¹,Grenon Muriel¹,Lowndes Noel F.¹

Affiliation:

1. Genome Stability Laboratory, Centre for Chromosome Biology and National Centre for Biomedical Engineering Science, National University of Ireland, Galway, University Road, Galway, Ireland

Abstract

53BP1 (p53-binding protein 1) is classified as a mediator/adaptor of the DNA-damage response, and is recruited to nuclear structures termed foci following genotoxic insult. In the present paper, we review the functions of 53BP1 in DNA-damage checkpoint activation and DNA repair, and the mechanisms of its recruitment and activation following DNA damage. We focus in particular on the role of covalent histone modifications in this process.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/37/4/897/546359/bst0370897.pdf

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