PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain-Reference-Cited by-同舟云学术

PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain

Published:2015-04-17 Issue:3 Volume:467 Page:461-472
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Jensen Thomas E.¹,Ross Fiona A.²,Kleinert Maximilian¹,Sylow Lykke¹,Knudsen Jonas R.¹,Gowans Graeme J.²,Hardie D. Grahame²,Richter Erik A.¹

Affiliation:

1. Department of Nutrition, Exercise and Sports, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen, Denmark

2. Division of Cell Signalling & Immunology, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U.K.

Abstract

PT-1 activates AMP-activated protein kinase (AMPK)-γ1- but not-γ3-containing complexes in mouse muscle, but PT-1 activates all three γ isoforms in HEK293 cells. PT-1 activates AMPK not by direct binding to α subunits, but by inhibiting the respiratory chain and increasing cellular AMP.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/467/3/461/681971/bj4670461.pdf

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