AMPK: Regulating Energy Balance at the Cellular and Whole Body Levels-Reference-Cited by-同舟云学术

AMPK: Regulating Energy Balance at the Cellular and Whole Body Levels

Published:2014-03 Issue:2 Volume:29 Page:99-107
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Hardie D. Grahame¹,Ashford Michael L. J.¹

Affiliation:

1. Division of Cell Signalling & Immunology, College of Life Sciences, and Division of Cardiovascular and Diabetes Medicine, College of Medicine, Dentistry & Nursing, University of Dundee, Dundee, Scotland, United Kingdom

Abstract

AMP-activated protein kinase appears to have evolved in single-celled eukaryotes as an adenine nucleotide sensor that maintains energy homeostasis at the cellular level. However, during evolution of more complex multicellular organisms, the system has adapted to interact with hormones so that it also plays a key role in balancing energy intake and expenditure at the whole body level.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00050.2013

Reference84 articles.

1. Hypothalamic CaMKK2 Contributes to the Regulation of Energy Balance

2. AMP-activated Protein Kinase Plays a Role in the Control of Food Intake

3. UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

4. The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans

5. A central integrator of transcription networks in plant stress and energy signalling

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