Thiamin biosynthesis: still yielding fascinating biological chemistry-Reference-Cited by-同舟云学术

Thiamin biosynthesis: still yielding fascinating biological chemistry

Published:2012-05-22 Issue:3 Volume:40 Page:555-560
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Begley Tadhg P.¹,Ealick Steven E.²,McLafferty Fred W.²

Affiliation:

1. Department of Chemistry, Texas A&M University, College Station, TX 77843, U.S.A.

2. Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, U.S.A.

Abstract

The present paper describes the biosynthesis of the thiamin thiazole in Bacillus subtilis and Saccharomyces cerevisiae. The two pathways are quite different: in B. subtilis, the thiazole is formed by an oxidative condensation of glycine, deoxy-D-xylulose 5-phosphate and a protein thiocarboxylate, whereas, in S. cerevisiae, the thiazole is assembled from glycine, NAD and Cys205 of the thiazole synthase.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/40/3/555/483399/bst0400555.pdf

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