Affiliation:
1. Dipartimento di Scienze dell'Invecchiamento, Policlinico Umberto I, Università “La Sapienza”, 00161 Rome, Italy
Abstract
Autonomic nervous system control in subjects with vasovagal syncope is controversial. In the present study, we used short-term spectral analysis to evaluate autonomic control in subjects with recurrent vasovagal syncope. We assessed the ability of spectral indices of HR (heart rate) variability to predict tilt-test responses. A series of 47 outpatients with recurrent vasovagal syncope and with positive responses to head-up tilt testing underwent a further study of RR variability during controlled breathing at rest and during tilt testing. During controlled breathing, RR interval variability of total power (TPRR; P<0.001), low-frequency power (LFRR; P<0.05), high-frequency power (HFRR; P<0.001) and HF expressed in normalized units (HFnuRR; P<0.001) were all higher, and LF expressed in normalized units (LFnuRR) and LF/HF ratio were lower in subjects with vasovagal syncope than in controls (P<0.001). To assess the ability of spectral components of RR variability to predict tilt-test responses, we prospectively studied 109 subjects with recurrent vasovagal syncope. The two normalized measures, HFnuRR and LFnuRR, determined during controlled breathing alone predicted a positive tilt-test response (sensitivity, 76%; specificity, 99%; positive predictive value, 96%; and negative predictive value, 90%). During tilting, subjects with vasovagal syncope had lower SBP (systolic blood pressure; P<0.05), LF component of peak SBP variability (LFSBP) and LFnuRR than controls, and higher TPRR, HFRR, HFnuRR and α HF (P<0.001). These spectral data indicate that vagal sinus modulation is increased at rest in subjects with vasovagal syncope. Spectral analysis of RR variability during controlled breathing, a procedure that predicts tilt-test responses, could be a useful guide in choosing the method of tilt testing.
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39 articles.
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