1. From the Division of Clinical Pharmacology, DuPont Pharmaceuticals, Wilmington, Del (R.M.-G., R.F.-V.); Centro Ricerche Cardiovascolari, CNR, Medicina Interna II, Ospedale “L. Sacco,” Università di Milano, Italy (R.F.); and Clinic Bavaria Kreischa, Department of Diabetes and Endocrinology, Keischa, Germany (J.T.).