Structural analysis of foot-and-mouth disease virus 3C protease: a viable target for antiviral drugs?-Reference-Cited by-同舟云学术

Structural analysis of foot-and-mouth disease virus 3C protease: a viable target for antiviral drugs?

Published:2007-05-22 Issue:3 Volume:35 Page:594-598
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Curry S.¹,Roqué-Rosell N.²,Sweeney T.R.¹,Zunszain P.A.¹,Leatherbarrow R.J.²

Affiliation:

1. Biophysics Section, Division of Cell and Molecular Biology, Blackett Laboratory, Imperial College, Exhibition Road, London SW7 2AZ, U.K.

2. Biological and Biophysical Chemistry Section, Department of Chemistry, Imperial College, Exhibition Road, London SW7 2AZ, U.K.

Abstract

Foot-and-mouth disease virus causes a major global agricultural problem that is difficult to control with existing vaccines. Structural analyses of the viral 3C protease not only have provided fresh insights into the catalytic mechanism of an unusual class of chymotrypsin-like cysteine proteases, but also are generating valuable information to drive the quest for effective antiviral therapies.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/35/3/594/541752/bst0350594.pdf

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5. Crystallization of foot-and-mouth disease virus 3C protease: surface mutagenesis and a novel crystal-optimization strategy

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