Structure of Senecavirus A 3C Protease Revealed the Cleavage Pattern of 3C Protease in Picornaviruses-Reference-Cited by-同舟云学术

Structure of Senecavirus A 3C Protease Revealed the Cleavage Pattern of 3C Protease in Picornaviruses

Published:2022-07-13 Issue:13 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Meng Kaiwen¹^ORCID,Zhang Lijie¹²,Xue Xiaoyin³,Xue Qinghong³,Sun Miao³,Meng Geng¹^ORCID

Affiliation:

1. College of Veterinary Medicine, China Agricultural University, Beijing, China

2. Joint National Laboratory for Antibody Drug Engineering, Henan University, Kaifeng, China

3. Department of Viral Biologics, China Institute of Veterinary Drug Control, Beijing, China

Abstract

Picornaviridae is a group of RNA viruses that harm both humans and livestock. 3C pro is an essential enzyme for picornavirus maturation, which makes it a promising target for antiviral drug development and a critical component for virus-like particle (VLP) production. However, the current challenge in the development of antiviral drugs and VLP vaccines includes the limited knowledge of how subsite structure determines the 3C pro cleavage pattern.

Funder

MOST | National Key Research and Development Program of China

Natural Science Foundation of Hebei Province

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00736-22

Reference50 articles.

1. Complete genome sequence analysis of Seneca Valley virus-001, a novel oncolytic picornavirus

2. Update on Senecavirus Infection in Pigs