An overview of the fission yeast septation initiation network (SIN)

Author:

Krapp Andrea1,Simanis Viesturs1

Affiliation:

1. Cell Cycle Control Laboratory, Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 155 chemin des Boveresses, 1066 Epalinges s/Lausanne, Switzerland

Abstract

The fission yeast septation initiation network, or SIN, is a signal transduction network that is required for septum formation in Schizosaccharomyces pombe. Its activity is tightly regulated through the cell cycle, to ensure proper co-ordination of mitosis and cytokinesis. SIN signalling requires three protein kinases for its function and is mediated by a ras-superfamily GTPase. We discuss the elements of the SIN and how they are regulated.

Publisher

Portland Press Ltd.

Subject

Biochemistry

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