Impact of Active Case Finding on Clinical Structure and Severity of Tuberculosis in School-Aged Children (7-15 Years Old)

Author:

Аksenova V. А.1ORCID,Gordina А. V.2,Sterlikov S. А.2ORCID,Kudlay D. А.3ORCID,Kucheryavaya D. А.2,Doktorova N. P.4ORCID

Affiliation:

1. National Medical Research Center of Phthisiopulmonology and Infectious Diseases; I. M. Sechenov First Moscow State Medical University (Sechenov University)

2. Federal Research Institute for Health Organization and Informatics

3. I. M. Sechenov First Moscow State Medical University (Sechenov University); Immunology Research Institute by the Federal Medical Biological Agency

4. National Medical Research Center of Phthisiopulmonology and Infectious Diseases

Abstract

The objective: to evaluate the impact of active case finding in children 7-15 years old on the clinical structure of tuberculosis and epidemic risk of detected patients.Subjects and Methods: 1,679 children aged 7-15 ill with tuberculosis.Result. The following has been observed in active case finding of tuberculosis versus tuberculosis detection when the patient is seeking medical care: A 9-fold reduction in the risk of disseminated and generalized tuberculosis; a 4.5-fold reduction in the risk of epidemically dangerous cases of tuberculosis; a 6-fold reduction in the risk of destructive forms of pulmonary tuberculosis. Cases of extrapulmonary tuberculosis were more frequently detected when patients were seeking medical care.Thus, the strategy adopted in Russia for active tuberculosis detection in children leads to significant results: preventing the spread of tuberculous infection in children's communities and reducing the proportion of severe forms of tuberculosis that create the risk of disability and death from tuberculosis.

Publisher

LLC "Medical Knowledge and Technologies"

Subject

General Medicine

Reference18 articles.

1. Аksenova V.А., Gordina А.V., Sterlikov S.А., Kucheryavaya D.А. Frequency rate of BCG vaccination and selected indicators of clinical characteristics of tuberculosis in schoolage children. Pediatriya, 2021, no. 5 (100), pp. 124-130. (In Russ.) doi: 10.24110/0031-403X-2021-100-5-124-130.

2. Аksenova V.А., Sterlikov S.А., Belilovsky E.M., Kazykina T.N., Rusakova L.I. Tuberculosis epidemiology in children. Sovremennye Problemy Zdravookhraneniya i Meditsinskoy Statistiki, 2019, no. 1, pp. 8-43. (In Russ.) doi: 10.24411/2312-2935-2019-10002.

3. Baryshnikova L.А., Аksenova V.А., Klevno N.I. Detection and differential diagnostics of tuberculosis in children and adolescents. Tuberculosis and Lung Diseases, 2017, vol. 95, no. 9, pp. 34-39. (In Russ.)

4. Gubkina M.F., Sterlikova S.S. The importance of screening methods of examination of children for tuberculosis detection of tuberculosis. Vestnik TSNIIT, 2019, no. 3, pp. 13-19. (In Russ.) doi: 10.7868/S2587667819030026.

5. Nechaeva O.B. Tuberculosis among children in Russia. Tuberculosis and Lung Diseases, 2000, vol. 98, no. 11, pp. 12-20. (In Russ.) doi: 10.21292/2075-1230-2020-98-11-12-20.

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