Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease

Author:

Llibre-Guerra Jorge J.1,Li Yan2,Schindler Suzanne E.1,Gordon Brian A.3,Fagan Anne M.14,Morris John C.156,Benzinger Tammie L. S.3,Hassenstab Jason1,Wang Guoqiao7,Allegri Ricardo8,Berman Sarah B.39,Chhatwal Jasmeer10,Farlow Martin R.11,Holtzman David M.156,Jucker Mathias712,Levin Johannes131415,Noble James M.16,Salloway Stephen17,Schofield Peter1819,Karch Celeste20,Fox Nick C.21,Xiong Chengjie2,Bateman Randall J.1,McDade Eric1

Affiliation:

1. Department of Neurology, Washington University in St Louis, St Louis, Missouri

2. Department of Biostatistics, Washington University in St Louis, St Louis, Missouri

3. Department of Radiology, Washington University in St Louis, St Louis, Missouri

4. Department of Pathology and Immunology, Washington University School of Medicine in St Louis, St Louis, Missouri

5. Hope Center for Neurological Disorders, St Louis, Missouri

6. Knight Alzheimer’s Disease Research Center, St Louis, Missouri

7. Hertie Institute for Clinical Brain Research, Department of Cellular Neurology, University of Tübingen, Tübingen, Germany

8. Department of Cognitive Neurology, Institute for Neurological Research Fleni, Buenos Aires, Argentina

9. Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania

10. Massachusetts General Hospital, Harvard Medical School, Boston

11. Neuroscience Center, Indiana University, Bloomington

12. DZNE-German Center for Neurodegenerative Diseases, Tübingen, Tübingen, Germany

13. Department of Neurology, Ludwig-Maximilians-University, Munich, Germany

14. DZNE-German Center for Neurodegenerative Diseases, Munich, Munich, Germany

15. SyNergy, Munich Cluster for Systems Neurology, Munich, Germany

16. Taub Institute for Research on Alzheimer’s Disease, Aging Brain G.H. Sergievsky Center, Department of Neurology, Columbia University Medical Center, New York, New York

17. Memory & Aging Program, Butler Hospital, Brown University, Providence, Rhode Island

18. Neuroscience Research Australia, Randwick, Sydney, New South Wales, Australia

19. School of Medical Sciences, UNSW Sydney, Sydney, New South Wales, Australia

20. Department of Psychiatry, Washington University in St Louis, St Louis, Missouri

21. Dementia Research Centre, University College London, London, United Kingdom

Publisher

American Medical Association (AMA)

Subject

General Medicine

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