Efficacy of Niclosamide vs Placebo in SARS-CoV-2 Respiratory Viral Clearance, Viral Shedding, and Duration of Symptoms Among Patients With Mild to Moderate COVID-19-Reference-Cited by-同舟云学术

Efficacy of Niclosamide vs Placebo in SARS-CoV-2 Respiratory Viral Clearance, Viral Shedding, and Duration of Symptoms Among Patients With Mild to Moderate COVID-19

Published:2022-02-09 Issue:2 Volume:5 Page:e2144942
ISSN:2574-3805
Container-title:JAMA Network Open
language:en
Short-container-title:JAMA Netw Open

Author:

Cairns Dana M.¹,Dulko Dorothy²³,Griffiths Jeffrey K.⁴⁵,Golan Yoav³⁵,Cohen Theodora²,Trinquart Ludovic³,Price Lori Lyn³,Beaulac Kirthana R.⁶,Selker Harry P.²³

Affiliation:

1. Department of Biomedical Engineering, Tufts University, Medford, Massachusetts

2. Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts

3. Tufts Clinical and Translational Science Institute, Tufts University, Boston, Massachusetts

4. Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts

5. Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, Massachusetts

6. Department of Pharmacy, Emerson Hospital, Concord, Massachusetts

Publisher

American Medical Association (AMA)

Subject

General Medicine

Link

https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2788857/cairns_2022_oi_211243_1643816437.26522.pdf

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4. Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs.;Jeon;Antimicrob Agents Chemother,2020

5. Niclosamide is a proton carrier and targets acidic endosomes with broad antiviral effects.;Jurgeit;PLoS Pathog,2012

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