Inhibition of Severe Acute Respiratory Syndrome Coronavirus Replication by Niclosamide-Reference-Cited by-同舟云学术

Inhibition of Severe Acute Respiratory Syndrome Coronavirus Replication by Niclosamide

Published:2004-07 Issue:7 Volume:48 Page:2693-2696
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wu Chang-Jer¹,Jan Jia-Tsrong¹,Chen Chi-Min²,Hsieh Hsing-Pang³,Hwang Der-Ren³,Liu Hwan-Wun¹,Liu Chiu-Yi¹,Huang Hui-Wen¹,Chen Su-Chin¹,Hong Cheng-Fong¹,Lin Ren-Kuo³,Chao Yu-Sheng³,Hsu John T. A.³

Affiliation:

1. Institute of Preventive Medicine, National Defense Medical College, National Defense University

2. Animal Technology Institute Taiwan, Miaoli, Taiwan

3. Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taipei

Abstract

ABSTRACT Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 μM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.7.2693-2696.2004

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