High Interindividual Variability of Methadone Enantiomer Blood Levels to Dose Ratios

Author:

Eap C. B.1,Bertschy G.1,Baumann P.1,Finkbeiner T.1,Gastpar M.1,Scherbaum N.2

Affiliation:

1. Département Universitaire de Psychiatrie Adulte, Unité de Biochimie et Psychopharmacologie Clinique, CH-1008 Prilly-Lausanne, Switzerland

2. Essen, Germany

Publisher

American Medical Association (AMA)

Subject

Psychiatry and Mental health,Arts and Humanities (miscellaneous)

Reference10 articles.

1. Methadone concentrations in plasma and their relationship to drug dosage.;Wolff;Clin Chem,1992

2. The mu(1), mu(2), delta, kappa opioid receptor binding profiles of methadone stereoisomers and morphine.;Kristensen;Life Sci,1994

3. Replacement of (R)-methadone by a double dose of (R,S)-methadone in addict patients: interindividual variability of the (R)/(S) ratios and evidence of adaptive changes in methadone pharmacokinetics.;Eap;Eur J Pharmacol,1996

4. Fluvoxamine and fluoxetine do not interact in the same way with the metabolism of the enantiomers of methadone.;Eap;J Clin Psychopharmacol,1997

5. Ultrarapid hydroxylation of debrisoquine in a Swedish population: analysis of the molecular genetic basis.;Dahl;J Pharmacol Exp Ther,1995

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