Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease

Author:

Mosley Jonathan D.12,Gupta Deepak K.1,Tan Jingyi3,Yao Jie3,Wells Quinn S.14,Shaffer Christian M.1,Kundu Suman1,Robinson-Cohen Cassianne15,Psaty Bruce M.6,Rich Stephen S.7,Post Wendy S.89,Guo Xiuqing3,Rotter Jerome I310,Roden Dan M.124,Gerszten Robert E.11,Wang Thomas J.12

Affiliation:

1. Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

2. Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee

3. Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, California

4. Department of Pharmacology, Vanderbilt University, Nashville, Tennessee

5. Vanderbilt O'Brien Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, Tennessee

6. Departments of Medicine, Epidemiology and Health Services, University of Washington School of Public Health; and Kaiser Permanente Washington Health Research Institute, Seattle, Washington

7. Department of Public Health Sciences, Center for Public Health Genomics, Charlottesville, Virginia

8. Department of Medicine, Johns Hopkins University, Baltimore, Maryland

9. Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland

10. Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Department of Medicine, Torrance, California12

11. Beth Israel Deaconess Medical Center, Division of Cardiovascular Medicine, Boston, Massachusetts

12. Department of Internal Medicine, University of Texas Southwestern Medical Center

Publisher

American Medical Association (AMA)

Subject

General Medicine

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