Down Syndrome in a New Era for Alzheimer Disease-Reference-Cited by-同舟云学术

Down Syndrome in a New Era for Alzheimer Disease

Published:2023-12-12 Issue:22 Volume:330 Page:2157
ISSN:0098-7484
Container-title:JAMA
language:en
Short-container-title:JAMA

Author:

Rafii Michael S.¹,Fortea Juan²³

Affiliation:

1. Alzheimer’s Therapeutic Research Institute, Keck School of Medicine of University of Southern California, San Diego

2. Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

3. Catalan Foundation for Down Syndrome, Barcelona, Spain

Abstract

This Viewpoint explains the genetic association between Alzheimer disease and Down syndrome and the negative impact of excluding people with Down syndrome from clinical trials on treatment for Alzheimer disease.

Publisher

American Medical Association (AMA)

Subject

General Medicine

Link

https://jamanetwork.com/journals/jama/articlepdf/2812402/jama_rafii_2023_vp_230145_1701364723.92763.pdf

Reference9 articles.

1. Lecanemab in early Alzheimer’s disease.;van Dyck;N Engl J Med,2023

2. Donanemab in early symptomatic Alzheimer disease: the TRAILBLAZER-ALZ 2 randomized clinical trial.;Sims;JAMA,2023

3. Alzheimer’s disease associated with Down syndrome: a genetic form of dementia.;Fortea;Lancet Neurol,2021

4. Association of Alzheimer disease with life expectancy in people with Down syndrome.;Iulita;JAMA Netw Open,2022

5. Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer’s disease.;Carmona-Iragui;Alzheimers Dement,2017

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1. Lecanemab and Vascular-Amyloid Deposition in Brains of People With Down Syndrome;JAMA Neurology;2024-08-19

2. Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer’s disease with APPdup and Down syndrome;Acta Neuropathologica;2024-07-18

3. Practicalities (and real‐life experiences) of dementia in adults with Down syndrome;American Journal of Medical Genetics Part C: Seminars in Medical Genetics;2024-07-05

4. Comparing research attitudes in Down syndrome and non‐Down syndrome research decision‐makers;Alzheimer's & Dementia: Translational Research & Clinical Interventions;2024-07

5. Assessing amyloid PET positivity and cognitive function in Down syndrome to guide clinical trials targeting amyloid;Alzheimer's & Dementia;2024-06-28