Practicalities (and real‐life experiences) of dementia in adults with Down syndrome-Reference-Cited by-同舟云学术

Practicalities (and real‐life experiences) of dementia in adults with Down syndrome

Published:2024-07-05 Issue: Volume: Page:
ISSN:1552-4868
Container-title:American Journal of Medical Genetics Part C: Seminars in Medical Genetics
language:en
Short-container-title:American J of Med Genetics Pt C

Author:

Harisinghani Ayesha¹^ORCID,Cottrell Clorinda¹,Donelan Karen²³,Lam Alice D.⁴,Pulsifer Margaret⁵⁶,Santoro Stephanie L.¹⁷^ORCID

Affiliation:

1. Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics Massachusetts General Hospital Boston Massachusetts USA

2. The Mongan Institute Survey Research Unit, MGH Boston Massachusetts USA

3. Heller School for Social Policy and Management Brandeis University Waltham Massachusetts USA

4. Department of Neurology Massachusetts General Hospital Boston Massachusetts USA

5. Psychology Assessment Center Massachusetts General Hospital Boston Massachusetts USA

6. Department of Psychiatry Harvard Medical School Boston Massachusetts USA

7. Department of Pediatrics Harvard Medical School Boston Massachusetts USA

Abstract

AbstractAdults with down syndrome (DS) have a lifetime dementia risk in excess of 95%, with a median age of onset of 55 years, due to trisomy 21. Co‐occurring Alzheimer's disease (AD) has increased morbidity and mortality, and it is now recommended to screen for AD in all adults with DS beginning at 40 years of age. In this manuscript, we present two clinical cases of adults with DS who developed AD summarizing their medical histories, presenting symptoms, path to diagnosis and psychosocial aspects of care collected from retrospective chart review with caregiver consent. These two cases were chosen due to their complexity and interwoven nature of the medical and psychosocial aspects, and highlight the complexity and nuance of caring for patients with DS and AD.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajmg.c.32098

Reference32 articles.

1. Revisiting FDA Approval of Aducanumab

2. Alzheimer's Association.2024.Alzheimer's Association ‐ Education programs. Accessed April 2 2024.https://www.alz.org/manh/helping_you/community_family_education

3. Down syndrome

4. Grief and its Complications in Individuals with Intellectual Disability

5. Health Supervision for Children and Adolescents With Down Syndrome