Target Trial Emulation-Reference-Cited by-同舟云学术

Target Trial Emulation

Published:2022-12-27 Issue:24 Volume:328 Page:2446
ISSN:0098-7484
Container-title:JAMA
language:en
Short-container-title:JAMA

Author:

Hernán Miguel A.¹,Wang Wei²,Leaf David E.³

Affiliation:

1. CAUSALab, Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts

2. Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts

3. Division of Renal Medicine, Brigham and Women’s Hospital, Boston, Massachusetts

Abstract

This Guide to Statistics and Methods describes the use of target trial emulation to design an observational study so it preserves the advantages of a randomized clinical trial, points out the limitations of the method, and provides an example of its use.

Publisher

American Medical Association (AMA)

Subject

General Medicine

Link

https://jamanetwork.com/journals/jama/articlepdf/2799678/jama_hernn_2022_gm_220007_1671489013.65036.pdf

Reference10 articles.

1. Using big data to emulate a target trial when a randomized trial is not available.;Hernán;Am J Epidemiol,2016

2. Association between early treatment with tocilizumab and mortality among critically ill patients with COVID-19.;Gupta;JAMA Intern Med,2021

3. Immortal time bias in observational studies.;Yadav;JAMA,2021

4. Specifying a target trial prevents immortal time bias and other self-inflicted injuries in observational analyses.;Hernán;J Clin Epidemiol,2016

5. Observational studies analyzed like randomized experiments: an application to postmenopausal hormone therapy and coronary heart disease.;Hernán;Epidemiology,2008

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